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KMID : 1161220210640060286
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Clinical and Experimental Pediatrics
2021 Volume.64 No. 6 p.286 ~ p.292
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Association between pesticide and polychlorinated biphenyl exposure during pregnancy and autism spectrum disorder among children: a meta-analysis
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Mehri Fereshteh
Bashirian Saeid
Khazaei Salman
Jenabi Ensiyeh
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Abstract
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Background: The effect of exposure to environmental factors on autism spectrum disorders (ASD), especially during pregnancy, is unclear.
Purpose: This meta-analysis investigated the association between exposure to pesticides and polychlorinated biphenyls (PCBs) during pregnancy and ASD risk among children.
Methods: We searched Scopus, PubMed, Web of Science, and ProQuest for articles published through September 2019. Random-effects models were used to examine the association among studies using pooled odds ratios (ORs) and their 95% confidence intervals (CI). I2 tests were used to measure interstudy heterogeneity.
Results: The pooled OR indicated a significant association between PCB and pesticide exposure during pregnancy and ASD risk among children (OR, 1.80; 95% CI, 1.26?2.34; and OR, 1.20; 95% CI, 1.02?1.39), respectively.
Conclusion: Findings of the present study indicate that exposure to pesticides and PCBs during pregnancy may affect the risk of ASD among children.
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KEYWORD
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Autism spectrum disorders, Autism, Metaanalysis, Polychlorinated biphenyls, Pesticides
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